The University of Arizona Electronic Theses and Dissertations - Details
| Full Text | urn:etd:azu_etd_2008_1_m |
| Title | Sensate Scaffolds for Articular Cartilage Repair |
| Author | Cody Larry Bliss |
| Affiliation | University of Arizona |
| Advisor | John A Szivek |
| Date | 2007-5-18 00:00:00 |
| Degree | Ph.D. |
| Language | English |
| Major | Biomedical Engineering |
| Keywords |
In vivo pressure Scaffolds Tissue Engineering Cartilage |
| Abstract | Polymer scaffold use has become commonplace in tissue engineering strategies. Scaffolds provide sturdy interfaces that securely anchor tissue engineered constructs to their designated locations. Researchers have used scaffolds to provide support to developing tissues as well as a growth template to aid the development of the desired phenotypic structure. In addition to using scaffolds for their mechanical support, scaffolds can be used as a diagnostic tool by attaching sensors. Strain gauge sensors have been attached to scaffolds to monitor compression and elongation. These polybutylterphalate (PBT) scaffolds were used in a cartilage tissue-engineering project for femoral cartilage repair. The aim of this project was to measure native cartilage pressure in normal canine stifle joints using strain gauge scaffolds. By using pressure sensitive films to confirm joint surface pressures determined with strain gauge measurements, "sensate" scaffolds were created to be able to provide in vivo joint loading measurements. An understanding of the in vivo pressures in the menisco-femoral joint space will facilitate the development of tissue engineered cartilage by determining chondrocyte mechanical triggers as well as helping define reasonable expectations for engineered articular cartilage tissue that is required for successful cartilage repair. |
| Hash Code | SHA-1 SUN 0x703ffd446ff12c2e065a86e48c03f4488bf331e2 |
| Attachments |